Black seed oil is a substance that is extracted from the seeds of Nigella sativa, a plant that is native to Egypt, the sub-continent and Asia. Black seed and black seed oil have long been used as herbal medicine for skin conditions, such as eczema, psoriasis, acne and dry skin, allergies, colds and more serious health conditions, such as asthma, arthritis, cancer and diabetes.
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Zeitlin adds that it's probably best not to use this oil for cooking itself, but "more as a flavor addition afterwards," she says. "So you can mix it into your stir-fry once you have plated your meal." In addition to seconding the salad dressing idea, Zeitlin also recommends mixing it into your smoothie, tea, or latte. The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.
According to a case report conducted by Onifade et al., after treatment with 10 mL of black seed twice daily for 6 months, a complete regaining and seroreversion of a 46-year-old HIV positive patient was evidenced [117]. In addition, a 27-year-old HIV infected woman was diagnosed during ante-natal care; she was not eligible for antiretroviral therapy; hence herbal therapist initiated her on black cumin and honey mixture (10 mL) thrice daily for a year. The repeat serology assessments for HIV infection became negative with undetectable viral load. The woman also got 3 children (2007, 2010, and 2012) that all were breastfed and none of the children infected with HIV and her repeat CD4 count was not less than 750 cells/μL [118]. Nowadays HIV/AIDS is a serious global threat and in this regard, N. sativa can be a promising natural therapy to cure such a chronic infectious disease, after validating its full therapeutic efficacy by further investigations.
The anti-inflammatory properties of black seed oil may also help alleviate symptoms like indigestion, nausea, abdominal distention, bloating, vomiting, diarrhea, or constipation. Some clinical studies have shownTrusted Source that the oil may even have a preventive effect on colitis, pancreatitis, and other gastrointestinal disorders. However, more research is necessary to pin down the exact benefits of black seed oil in this area.
Black Cumin Seed OilBlack seed might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Using black seed along with sedative medications might cause too much sleepiness. Some sedative medications include Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
The maximal nutritional value of black cumin can be linked to the presence of substantial amount of vegetable protein, fiber and minerals, and vitamins. The nutritional composition reported from different sources revealed 20-85% of protein, 38.20% of fat, 7-94% of fiber, and 31.94% of total carbohydrates. Among various amino acids identified, glutamate, arginine, and aspartate while cysteine and methionine were the major and minor amino acids, respectively. Black cumin seeds also contain significant levels of iron, copper, zinc, phosphorus, calcium, thiamin, niacin, pyridoxine, and folic acid [7, 8]. In addition, phytochemical analyses of N. sativa displayed the presence of over hundreds of phytoconstituents which include mainly alkaloids, saponins, sterols, and essential oil but the composition of many of these have not been chemically recognized nor have been biologically verified. The N. sativa seed contain 26-34% fixed oil of which the major fatty acids are linoleic acid (64.6%) and palmitic acid (20.4%). The seed oil is comprised of 0.4%–2.5% essential oil [9, 10]. Amongst different active constituents reported so far, thymoquinone found as major component of the essential oil is the most bioactive compound and exhibits wide ranging therapeutic benefits [11].
